Understanding antibiotic resistance of Francisella ssp
Francisella tularensis is the causative agent in tularemia for which the high prevalence of treatment failure and relapse is a major concern. Using MS-based proteomics, we explore the proteomes of different Francisella strains to identify proteins that may contribute to reduced antibiotic susceptibility.
Collaborators
Patricia Renesto, Experimental Recombinant Therapy Team, TIMC-IMAG, Grenoble
EDyP project leader
Yohann Couté
INSERM engineer
Head of the Proteomic Application Department, EDyP-Service Manager
Publications
- Siebert, C., Lindgren, H., Ferré, S., Villers, C., Boisset, S., Perard, J., … Renesto, P. (2019). Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation. Emerging Microbes & Infections, 8(1), 808–822. https://doi.org/10.1080/22221751.2019.1615848
Funding
- FINOVI (Grant AO12-02, 2018-2020)
Image credit: National Institute of Allergy and Infectious Diseases (NIAID)/Flickr.